That's a tough one. The price difference is huge so my gut reaction would be for you to make the drive. BUT...that's a long drive. How far are you from Miami, Ft. Lauderdale or Tampa? Those markets might provide good fares...

I once (and ONLY once) drove to LA to make an Air Jamaica flight, that great one that would leave at 10:00pm and put you in MoBay at 6:00am the following day. The reason for the drive was we were being comped by AJ. Between the drives there and back ( we did not stay in LA overnight) it made for exhausting travel.

Now, I had friends in the SF Bay Area that would take a "commuter" flight such as on Southwest and somewhat successfully do this. Is this a cost efficient option for you?