There's a couple things you can do to ease your worry, however nothing is totall fool proof.
One: set up "find my iPhone/iPad" so that you could trace it if stolen. This will also allow you to "wipe it clean" remotely.
Two: screen lock so that someone can't get into it.
Three: set up a "burgler alarm" app to go off if it is moved. There are some free apps in the store. There's a code to disarm it, believe me you want to remember what it is!
With all that said, someone could still make off with it.
The iPad is nice for skype or face time if you have an internet connection.